Kyoto University Bulletin 2008-2009

SCHOOL OF PUBLIC HEALTH

EPIDEMIOLOGY AND BIOSTATISTICS

The fields put primary focus on the development in and teaching methodologies used for health research and practice. In order to improve public health and the therapeutic outcome of treatments, the four departments, Biostatistics, Epidemiology & Healthcare Research, Pharmacoepidemiology, and Genome Epidemiology are devoted to develop new epidemiological methodologies, to carry out the analysis of the quality of life and the outcomes for important difficult disorders, and to support developing new treatments, from the aspects of design and analysis for clinical trials, epidemiological studies, and outcomes research. Staff members are responsible for teaching those disciplines for graduate students.

DEPARTMENT OF BIOSTATISTICS

http://www.pbh.med.kyoto-u.ac.jp/english/html/dep1a.html

The Department of Biostatistics was established in 2000. Graduate students interested in the methods of biostatistics and the conduct of epidemiologic research and clinical trials are welcomed.

Outline of Teaching Activities:

This Department offers programs of study leading to a master's degree and a doctoral degree. The Master of Public Health (MPH) degree program is designed to provide basic training in biostatistics as applied to a broad spectrum of health-related problems. The doctoral degree program is designed to provide advanced, research oriented training in methods of biostatistics.

Outline of Research Activities:

Major research fields are biostatistics methodology and the conduct of epidemiologic studies and clinical trails. In methodological work, new epidemiologic study designs which are efficient and convenient are investigated for providing new sampling and analysis methods. Causal inference is the most challenging methodological research field. Estimation of causal parameters in experimental and observational studies is developing. Several collaborative studies in epidemiology and clinical trials are ongoing.

Professor:

SATO, Tosiya, D. Health Sc. (Univ. of Tokyo), 1. Epidemiologic methods; 2. Causal inference; 3. Collaborative studies in epidemiology and clinical trials

Associate Professor:

OHMORI, Takashi, D. Eng. (Tokyo Univ. of Sci.), 1. Biopharmaceutical statistics; 2. Alternative methods to Animal experiments; 3. Pharmacoepidemiology

DEPARTMENT OF EPIDEMIOLOGY

AND HEALTHCARE RESEARCH

Education:

The department's primary educational goal is to train graduate students in the basic concepts and methods of epidemiology and healthcare research, and thereby to prepare them for work in health-related fields. Three lecture courses and practicum will be offered; Epidemiology, Study Design, Designing Survey Research and Health Services Research. From Spring of 2005, a new Master program, Master of Clinical Research (MCR) was started and this department contributes to this program with new 5 course works (Protocol Development and Management, Clinical Biostatistics, Data Analysis, Decision Analysis, Medical Writing). Faculty members in the department also supervise doctoral students conducting original research.

Research:

Faculty and graduate students conduct observational and experimental studies both of patients and of populations. In general, those studies are of three types:

1. Clinical effectiveness research, in which the effectiveness of existing, and newly developed methods of diagnosis and therapy are assessed, often with the use of patient-based outcomes, such as health-related quality of life.

2. Methodological research, in which the methods used to measure and analyze health status and health outcomes (including health-related quality of life), those measurements are analyzed and interpreted for their clinical and social relevance.

3. Health Services Research, which studies methods to measure, and scientifically assesses strategies to improve quality of healthcare.

Professor:

FUKUHARA, Shunichi, M.D., M.Sc. (Harvard Univ.), D.Med.Sc. (Univ. of Tokyo), 1. Clinical epidemiology; 2. Outcomes research; 3. Health services research; 4. Health-related quality of life

Associate Professor:

YAMAZAKI, Shin, M.P.H., D., Ph.D. (Kyoto Univ.), 1. Environmental epidemiology; 2. Health related quality of life;

Assistant Professors:

HAYASHINO, Yasuaki, M.D., Ph.D. (Kyoto Univ.) 1.Clinical epidemiology; 2. Decision analysis; 3. Behavioral science

TAKEGAMI, Misa, R.N., M.P.H. (Kyoto Univ.),

1. Clinical epidemiology; 2. Outcomes research;

DEPARTMENT OF PHARMACOEPIDEMIOLOGY

Phone: +81-75-753-9769; Fax: +81-75-753-4469

URL: http://square.umin.ac.jp/kupe/

The Department of Pharmacoepidemiology was newly established in 2000 as the first official department for application and education in this field in Japan.

Pharmacoepidemiology is a natural crossing of scientific paths. Epidemiology is the study of disease occurrence, and Pharmacology aims to reduce disease incidence and prevalence through biochemical interventions. Pharmacoepidemiology can be defined as the application of epidemiologic reasoning, methods, and knowledge to the study of the uses and effects (beneficial and adverse) of drugs in human populations including clinical trials.

Outline of Teaching Activities:

The efficacy and safety of the drug and biologics are evaluated through the drug development process involving preclinical and clinical studies and post-marketing surveillance. The differences in the regulatory systems among Japan, US, EU, and Asian countries in terms of healthcare, science, and industry will be discussed.

Outline of Research Activities:

Current research activities are mainly focused on the clinical application of pharmacoepidemiologic methodologies. Individual research subject undertaken include:

1. Assessment on safety and effectiveness of drug and biologics and the research on clinical trial and drug approval systems by the regulatory agencies.

2. Research and development of targeted cancer therapeutics including immunotoxin/cytotoxins and cancer vaccines.

3. Research on the infrastructure of drug development using novel biotechnology and public acceptance of translational research.

4. Biostatistics on the clinical trials and clinical researches and pharmacogenomics research.

Professor:

KAWAKAMI, Koji, M.D. (Tsukuba Univ.), D.Med.Sc. (Yokohama City Univ.),

1.Regulatory science; 2.Anticancer molecular therapeutics and biologics;

Associate Professor:

HINOTSU, Shiro, M.D. (Tsukuda Univ.), D.Med.Sc (Tsukuba Univ.)

1 Design and analysis of clinical trials; 2. Urology;

Assistant Professors (Special Appointment):

KOHNO, Masayuki, D.Med.Sc. (Chiba Univ.), Molecular biology;

HORIBE, Tomohisa, D.Med.Sc. (Ritsumeikan Univ.), Molecular biology;

URUSHIHARA, Hisashi, D.Health.Sc. (Kyoto Univ.), Epidemiology, drug safety;

DEPARTMENT OF GENOME EPIDEMIOLOGY

Professor:

MATSUDA, Fumihiko, D.Med.Sc (Kyoto Univ.), 1. Molecular biology; 2. Human genetics;

For details, see Center for Genomic Medicine.

HEALTH ADMINISTRATION

This field deals with the policy making and administration in public health and health care in the context of ethical, economic and informational theories.

DEPARTMENT OF HEALTHCARE ECONOMICS

AND QUALITY MANAGEMENT

Phone +81-75-753-4454, Fax +81-75-753-4455

http://med-econ.umin.ac.jp/

The Department aims to contribute to the improvement of the quality and efficiency of health care systems by means of research, development, education and any other relevant professional activities. To tackle and solve problems of quality and cost in health and health care, the Department applies multi- and inter-disciplinary fields of quantitative and qualitative sciences and technologies. The uniqueness of the Department is that we develop "soft" technologies for actual use in health care management and policy.

The training and education aims to nurture highly professional experts and their network in this emerging field of healthcare quality, economics, management and policy. The Department also provides training for executives and young leaders in health care management. The Department stresses the interaction of gresearch and developmenth with greal-world systems and policiesh, with one of the goals to produce outputs for resource- and quality-based healthcare financing system together with effective management system and policy.

The research themes are: (1) Evaluation of quality, cost and efficiency of health care, including clinical performance, practice variation, technology transition, economic evaluation, technology assessment and information infrastructures for health, patient casemix classification, financial performance and costing systems; (2) Payment, reimbursement and insurance in health care and its related systems; (3) Management system in health care, including healthcare accreditation, management quality, organizational and financial management, safety and risk management, satisfaction and organizational culture. (4) Population-based assessment of health status, health-related resource consumption, demand and supply, and effects of interventions and system changes. (5) Analysis and planning of health care systems, policies and their performance, including projects granted by national/local governments and international agencies.

Professor:

IMANAKA, Yuichi, M.D., D.Med.Sc. (Univ. of Tokyo), M.P.H. (Univ. of Michigan), Ph.D. (Univ. of Michigan), 1. Quality, cost and performance of health care and its systems; 2. Management, policy and economics in health care;

Senior Lecturers:

SEKIMOTO, Miho, M.D. (Kyoto Pref. Med. Sch.), D.Med.Sc. (Kyoto Univ.), M.P.H.(Johns Hopkins Univ.), Quality of care;

HAYASHIDA, Kenshi, M.Sc. (Tokyo University), Ph.D. (Kyoto University), Healthcare Economics and Management;

Assistant Professor:

IKAI, Hiroshi, M.D. (Kyoto University), Healthcare Economics;

DEPARTMENT OF BIOMEDICAL ETHICS

The objectives of the courses that we offer are to enable students to gain an understanding of ethical issues in health care; familiarity with the major ethical approaches to, and philosophical reasoning, regarding moral decisions in the field of public health and clinical medicine; the ability to think critically about key issues in some of the most controversial areas of biomedical ethics; and the skills to design and implement one's own research project.

The courses, led by two full-time faculty members as well as several visiting lecturers will consist of lectures, small group discussion, and presentations by students of their research projects. On completion of the course, each student is expected to be able to recognize, analyze ethical arguments, and reach ethically sound decisions on their own. They are also expected to have acquired the abilities to bring a theoretical framework to the analysis and the evaluation of ethical issues in health care.

Professor:

KOSUGI, Shinji, M.D., D.Med.Sc. (Kyoto Univ.), 1. Biomedical ethics; 2. Clinical ethics; 3. Clinical Genetics;

Associate Professor:

NUMABE, Hironao, M.D., D.Med.Sc. (Tokyo Medical Univ.), 1. Biomedical ethics; 2. Clinical ethics; 3. Clinical Genetics;

DEPARTMENT OF HEALTH INFORMATICS

In todayfs society, the impact of health-related information on human behavior and health can be just as profound as, or in some cases, more profound than, the impact of physical environment on human health. This field of study explores how information can contribute to improve peoplefs health behavior/health-care-seeking behavior, and decision-making in both clinical setting and public health. The main topics to be covered are: Evidence-based healthcare (EBHC); decision analysis, health literacy & communication; epidemiologic research including genome approach, quantitative and qualitative assessment of health-related information e-Health; and information ethics.

Professor:

NAKAYAMA, Takeo, M.D., D.Med.Sc. (Tokyo Medical and Dental Univ.), 1. Health informatics; 2.Evidence-based healthcare; 3. Epidemiology;

DEPARTMENT OF MANAGEMENT OF TECHNOLOGY AND INTELLECTUAL PROPERTY

Phone +81-75-753-9332, Fax +71-75-753-9333

Along with paradigm change taking place on global scale, the universities are being counted upon by the public on their capability in handling these changes. Under much expectations from both industry and government sector, universities now have a role to contribute to society by leading the development of advanced scientific technologies from basic research to industrially applicable form.

The department aims to foster directors of intellectual property, a human resource essential in utilizing universityfs intellectual properties.

As well as equipping students with practical skills, department teaches both basic theories in medicine particularly in the field of advanced medicine, and in humanities and social science, particularly on the exploitation of intellectual property rights. The department aims to nurture directors of technology management, the personnel with the capability to discover, manage and exploit the intellectual property in the field of biotechnology, particularly in advanced medicine.

1. Natural Science: the course will give students top-level scientific knowledge and the knowledge on industrial demand through lectures by the academics who are engaged in researches of forefront science at the graduate school of medicine, and by the industrial professionals who hold abundant experience in translational research and development research in the industry.

2. Humanities and other Subject in School of Public Health: the department will give students basic knowledge of intellectual property laws and other social sciences through lectures by instructors selected for each specialization field. The practical skills and knowledge in accounting and market valuation and distribution of intellectual property (venture capital field) are taught through lectures by lecturer with a long career in business.

3. Practical Skills: Using the knowledge learned above as a base, the course will equip students with ability to act in real life situation through work experience at Kyoto University and through other externships, gaining experience in establishing rights in research out come and in exploitation of those rights.

At the Management of Technology and Intellectual Property, researches are being conducted on various problems faced in management and practical application of intellectual property rights. So far, research has been conducted on "Investigation for protection and utilization of intellectual property in translational research for purpose of establishing the management system" and "Systems of intellectual property management which can accommodate movement of researchers from one institution to another". The findings from these researches are reflected in the management of intellectual property at the university.

Professor:

TERANISHI, Yutaka, D.Eng. (Kyoto Univ.), 1. Molecular Biology; 2. Management of Technology;

Associate Professor:

ABE, Seiji, M. Agr. (Tohoku Univ.),

Assistant Professor:

SAOTOME, Chikako, D.Pharm.Sci. (Toho Univ.), 1. Management of Intellectual Property,

DEPARTMENT OF MEDICAL COMMUNICATION

Phone +81-75-753-4668

Medical Communication is a specialized area in medicine within science communication, which is currently enjoying national and international public attention. Kyoto University is the first in Japan to have established a department of Medical Communication in April, 2008 that investigates how medical knowledge is shared and circulated among different societal segments (eg., the public, media, policy makers, and the medical community) on a variety of levels (personal/micro, community/meso, social/macro, and international). The field of medical communication also explores how medicine communicates with society. Medical communication, therefore, is not the same as health communication, which is a well-known communication field researching a doctor-patient interaction, as the former has a more macro research domain. This new department welcomes students who are eager to not only tackle the aforementioned ambitious theme but also explore and claim the emerging field of medical communication.

First semester: In this semester, the course provides an introduction to medical communication, both its theoretical frameworks and applications, for those from diverse interests, backgrounds, and/or disciplines. In class, frames from communication studies, disability studies, and/or science communication are drawn, and an issue of communication channels is addressed. Second semester: Building upon the first semester, the course further explores current topics in medical communication, especially relations among the medical/research community, media, public, and policy makers.

Associate Professor:

IWAKUMA, Miho, Ph.D. (University of Oklahoma),

1. (Intercultural) communication; 2. Disability studies; 3. Aging with disability

HEALTH DETERMINANTS

This field encompasses the disciplines related to exploring the determinants of health, i.e., environmental factors and individual as well as population behavioral factors.

DEPARTMENT OF HEALTH AND

ENVIRONMENTAL SCIENCES

This department was established in 2000. The primary research and teaching endeavor is to provide scientific bases for occupational and environmental health. The research goal is approached by versatile methodologies mainly, genetic epidemiology and molecular toxicology. This department provides courses of occupational and environmental health to medical students and M.P.H. master students. For Ph. D. students we offer research courses for occupational and environmental health with emphasis on genetic factors and toxicology. The major fields of research include genetic epidemiology for cerebrovascular diseases and toxicology of persistent organic pollutants.

Professor:

KOIZUMI, Akio, M.D., D.Med.Sc. (Tohoku Univ.), Genetic epidemiology, occupational health and environmental sciences;

Senior Lecturer:

HARADA, Kouji, MPH, Dr.PH.Ph.D. (Kyoto Univ.), Environmental health sciences;

Assistant Professors:

MINATA, Mutsuko, M.D., D.Med.Sc. (Kyoto Univ.), Toxicology;

HITOMI, Toshiaki, M.D., D.Med.Sc. (Kyoto Prefectual Univ.), Genetic epidemiology, occupational health and environmental sciences;

DEPARTMENT OF HEALTH PROMOTION

AND HUMAN BEHAVIOR

The department offers lectures on the effect of lifestyles in the development of chronic disorders including cardiovascular, diabetes, obesity, allergies, and cancers. The department also offers lectures on human behavior given by part-time lectures how to educate populations with high risks to give up their bad lifestyles.

The department is collaborating with more than 30 research groups world-wide, and it enables students to involve ongoing international projects, which will assist them in writing high-quality academic papers.

Professor:

KOSUGI, Shinji, M.D., D.Med.Sc. (Kyoto Univ.), 1. Biomedical ethics; 2.Clinical ethics; 3.Clinical genetics;

Assistant Professor:

YAMASAKI, Akiko, D.Med.Sc. (Univ. of Tokyo), Social epidemiology.

INTERNATIONAL HEALTH

This program prepares health professionals for expected roles in international agencies and in collaborative overseas projects.

DEPARTMENT OF GLOBAL HEALTH

AND SOCIO-EPIDEMIOLOGY

Phone +81-75-753-4350

Fax +81-75-753-4359

Our department was established in April, 2000 in Kyoto University School of Public Health. Our department adopts a new discipline of social medicine which takes multifaceted approach that encompasses both medical and social sciences, or quantitative and qualitative research methods. We call this interdisciplinary approach esocio-epidemiologyf. Socio-epidemiology aims to restore the views and methodologies which biomedical science, that is epistemologically grounded in the tradition of logical positivism, has been lacking and attempts to improve the health of people on the basis of not only biomedical evidence but also on socio-cultural understanding of health, utilizing systematic social programming approach.

Outline of Research Activities:

Our research interest is exclusively focused on socio-epidemiological approach to HIV prevention in Japan as well as overseas based on quantitative and qualitative methods, behavioral theories, social marketing approach and social experimental methods. As principal investigators of multiple national HIV-related research groups, we have been involved in the behavioral and preventive studies on youth, immigrants and other various vulnerable subpopulations. International collaborative researches involve a bio-behavioral and preventive studies among drug users in Iran in collaboration with the Ministry of Health of Iran and UNDP/UNODC (2003-), and large-scale behavioral and preventive studies among university students in Zhejiang Province of China (2003-). In 2006, our department was appointed as a UNAIDS Collaborating Centre aiming at expansion of socio-epidemiological studies on HIV.

Outline of Teaching Activities:

In the first term, students will learn about the study design issues relevant to socio-epidemiology such as social marketing, non-probability sampling, social experimental design, social research methods and practical questionnaire development. To master socio-epidemiology, a series of lectures and workshops are held on qualitative research methods in the second term that are basic to socio-epidemiology such as in-depth interviews, focus group interviews, and qualitative data analysis. Throughout these courses students are expected to acquire an integrated view on socio-epidemiology and lay a solid foundation for the future research.

Professor:

KIHARA, Masahiro, M.D., D.Med.Sc. (Kyoto Univ.),

1. Socio-epidemiology; 2. HIV prevention;

Associate Professor:

ONO-KIHARA, Masako, M.Sc., D.Med.Sc. (Yokohama City Univ.), 1. Socio-epidemiology; 2.Molecular epidemiology; 3.HIV prevention; 4.Behavior epidemiology;

Assistant Professor:

ZAMANI, Saman, M.D., Ph.D. (Kyoto Univ.),

1. Socio-epidemiology; 2. HIV prevention; 3 Reduction of drug-related harm;

DEPARTMENT OF PUBLIC HEALTH AND

INTERNATIONAL HEALTH

The Department of Public Health and International Health was established in 1949 as the Department of Public Health, within the Faculty of Medicine. The Department was chaired successively by Professor Masashichi Nishio (1949-1973; medical care and welfare, toxicology of heavy metals and organic solvents), Professor Seiyo Sano (1973-1987; lead poisoning, porphyrin and heme biosynthesis) and Professor Masayuki Ikeda (1988-1996; occupational and environmental health, organic solvent poisoning and predictive toxicology). Dr Toshitaka Nakahara was appointed as Professor and Chairman of the Department in 1997.

At the time of the establishment of the School of Public Health in April 2000, the Department of Public Health became the Department of Public Health and Administration, which afresh became the Department of Public Health and International Health in May 2003. The Department is currently responsible for the courses offered to undergraduate students in medicine, graduate students in social medicine as well as graduate students enrolled in the School of Public Health.

Professor:

NAKAHARA, Toshitaka, M.D., D.Med.Sc. (Nihon Univ.), M.P.H. (Johns Hopkins Univ.), 1. Health policy and management; 2. International health;

Associate Professor:

SATOMURA, Kazunari, M.D., D. Med. Sc. (Kyoto Univ.),

1. Health education and promotion; 2. International health; 3. Food safety;

Assistant Professor:

IWANAGA, Suketaka, M.D., 1. Health education and promotion; 2. Health information; 3. International health;

SCHOOL OF HUMAN HEALTH SCIENCES,

FACULTY OF MEDICINE

Head of School: SASADA, Masataka, M.D., D.Med.Sc. (Kyoto Univ.)

53, Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, JAPAN

Tel: +81-75-751-3901

Fax: +81-75-751-3909

http://www.hs.med.kyoto-u.ac.jp/

DEPARTMENT OF NURSING

Nursing is the practical science which supports the people of all healthy level of individual, family and community. The Department of Nursing was established in 2003, but the precursor goes back until 1989. This department has the responsibility for the education of registered nurse, public health nurse and nurse midwife, and the researches in the nursing study area. There are four areas, eBasic Nursing Sciencef, eClinical Nursing Sciencef, eFamily Nursing Sciencef and eCommunity Health Nursing Science and Gerontological Nursing Sciencef in this department.

Basic Nursing Science is the fundamental area of nursing education. This area composed of Nursing theory, Environmental Health Nursing, Basic Nursing Techniques, and so on. This area aims to inspect for evidence of nursing practice and to develop the various method of evaluating the nursing techniques.

Clinical Nursing Science is composed chronic and critical adult nursing and psychiatric nursing. The education and research of chronic and critical adult nursing are focused on pre-post operative and transplant care, psycho-social care, patientfs education and to development of nursing knowledge and skill to maintain and promote for patientfs health. The psychiatric nursing is emphasized in psychiatric and health care and mental and physical rehabilitation care for both patients and their family to live at community.

Family Nursing Science is composed of pediatric nursing, womenfs health, maternity nursing and midwifery. The family nursing science is focused on sound growth and development of children, the safe and comfortable birth, and reproductive health/rights of women and so on, in order to keep and to promote physical, mental and social health of family members.

Community Health Nursing Science covers diverse subjects such as introduction to community health nursing, community health assessment, community health nursing, and some other subjects, in particular, in order to provide curriculum for public health nurses. Gerontological Nursing Science covers diverse subjects such as gerontological nursing, home care nursing and community care system in order to provide curriculum for home care nurses.

Basic Nursing Science

Professors:

MIYAJIMA, Asako, R.N., P.H.N., Ph.D., (Nara Womenfs Univ.), 1. Environmental health nursing; 2. Studies of living environment for client/patient; 3. Consultation about living environment for home care patients; 4. Development of sign communication system in hospital and ward; 5. Nursing theory; 6. Basic nursing techniques;

SUGA, Sawako, D.Ed. (Kyoto Univ.), Clinical psychology;

Associate Professor:

WAKAMURA, Tomoko, R.N., P.H.N., Ph.D. (Nara Womenfs Univ.), 1. Basic nursing techniques; 2. Sleep managements (Chronobiology, thermal and clothing physiology in sleep, sleep Environment, QOL of sleep disorder patients);

Assistant Professor:

SUZUKI, Kazuyo, R.N., P.H.N., M.A., 1. Nursing in society;

2. Basic nursing techniques;

Clinical Nursing Science

Professors:

EGAWA, Takako, R.N., M.S.N., Ph.D. (Osaka Univ.), 1. Area for education and research is self-care and foot care of diabetes and self-care of patient with dialysis treatment; 2. Clinical nursing for adults;

HOSODA, Kiminori, M.D., Ph.D. (Kyoto Univ.), 1. Endocrinology and Metabolism; 2. Diabetes Mellitus; 3. Obesity; 4. Molecular Medicine; 5. Internal Medicine;

HAYASHI, Yuko, R.N., P.H.N., M.S.N., Ph.D. (St.Lukefs College of Nursing), 1. Adult health nursing; 2. Transplantation nursing;

NOMOTO, Shinichi, M.D., Ph.D. (Kyoto Univ.),

1. Cardiovascular Surgery; 2. Critical care medicine;

SAITO, Yumi, R.N., M.S.N., Ph.D. (Jichi Med. School),

1. Hospital infection control; 2. Infection control nursing; 3. Immuno-psycho-oncology nursing; 4. Nursing theory 5. Basic nursing techniques;

SAKURABA, Shigeru, R.N., Ph.D. (Yamagata Univ.), 1. Patients with mental illness Care; 2. Psychiatric and mental health nursing; 3. Mental health; 4. Patient advice and liaison service; 5. Alexithymia; 6. Suicide; 7. Psychopharmacology; 8. Social welfare services;

Associate Professor:

AKAZAWA, Chiharu, R.N., M.S.N., Ph.D. (Kyoto Univ.),

1. Clinical nursing for adults; 2. Critical care; 3. Trans-plantation nursing care; 4. Stress-coping;

HONDA, Ikumi, R.N., C.N.M., Ph.D. (Osaka Univ.),

1. Clinical nursing for adult with diabetes; 2. Foot care for the adult and the elderly; 3. Health behavior and health education;

SAKUDA, Hiromi, R.N., P.H.N., Ph.D. (Hiroshima Univ.),

1. Cancer nursing; 2. Lymphedema care; 3. Nursing technical education methodology;

Assistant Professors:

SUMIKA, Masuko, R.N., P.H.N., M.S.N., Ph.D. (Osaka Univ.), 1. Practicum in adult nursing;

TAKAHASHI, Miwa, R.N., P.H.N., M.S., 1. Practicum in fundamental nursing;

KONISHI, Nami, R.N., P.H.N., Ph.D., (Yamanashi Univ.),

1. Practicum in mental health nursing;

Teaching Associate:

FUKUDA, Risa, R.N., P.H.N., M.P.H., 1. Practicum in adult nursing;

Family Nursing Science

Professors:

KABEYAMA, Kiyoko, R.N., R.M., M.S.N., Ph.D. (Nara Womenfs Univ.), 1. Midwifery; 2. Maternal and child health nursing; 3.Womenfs health; 4. Human sexuality;

SUGANUMA, Nobuhiko, M.D., Ph.D., 1. Obstetrics and gynecology; 2. Reproductive medicine; 3. Assisted reproductive technology; 4. Hormonal disorders;

Associate Professors:

YAGI, Keiko, R.N., N.M., P.H.N., M.N.S., 1. Midwifery; 2. Maternal and child health nursing; 3. Women's health nursing;

TANIGUCHI, Hatsumi, R.N., R.M., M.P.H., M.S.N., Ph.D.(Univ. of Hawaii at Manoa), 1. Womenfs health; 2. Midwifery; 3. Maternal and child health;

Senior Lecturer:

WATANABE, Hiroko, R.N., R.M., M.S.N., M.H.S., Ph.D.(Tokyo Univ.), 1. Midwifery; 2. Maternal and child health nursing;

Assistant Professors:

CHIBA, Yoko, R.N., R.M., M.P.H. (Boston Univ.), 1. Practicum in midwifery ; 2. Practicum in maternal and child health nursing;

KIYOKAWA, Kanako, R.N., P.H.N., M.S.N., 1. Practicum in pediatric nursing;

YAMAGUCHI, Kotomi, R.N., R.M., P.H.N., M.S.N., 1. Practicum in maternal and child health nursing; 2. Midwifery;

Community Health Nursing Science and Gerontological Nursing Science

Professors:

KATSURA, Toshiki, R.N., P.H.N., Ph.D. (Yamagata Univ.), 1. Lifestyle and metabolic syndrome; 2. Visual information processing relating to falls in elderly; 3. Successful aging 4. Cardiovascular disease prevention;

KINOSHITA, Ayae, M.D., D.Med.Sci. (Kyoto Univ.), 1. Neurology, Internal medicine; 2. Alzheimerfs disease and related disorders; 3. Gerontological nursing;

Associate Professor:

HOSHINO, Akiko, R.N., P.H.N., Ph.D. (Tohoku Gakuin Univ.),

1. Community organization; 2. Health behavior; 3. Health promotion; 4. Community health care system;

Assistant Professors:

USUI, Kanae, R.N., P.H.N., M.Health Sci. (Osaka Univ.),

1. Community health care system; 2. Supporting techniques of public health nurse;

KUBOTA, Masakazu, R.N., P.H.N., M.Med.Sci., Ph.D. (Nagoya Univ.),

1. Alzheimerfs disease and related disorders; 2. Gerontological nursing; 3. Dementia care system;

DEPARTMENT OF LABORATORY SCIENCE

Department of laboratory science has three courses as shown below. The outline of those courses is presented as follows.

Analysis of basic pathological information on organisms:

In the course, you will extract information from the genetic and molecular levels of organisms to the cellular and organic levels of animal body, and analyze the information from a wide variety of angles. As the basis for it, you will profoundly learn the functions and pathological conditions of the organisms concerned. You will thus equip yourself with the power of observation and thinking, as well as creativity for the analysis.

Analysis of clinical pathological information on organisms:

In the course, you will learn how to apply the information obtained from organisms to clinical diagnosis and therapy. You will also learn the fundamental theory and technology of advanced medical treatment, in order to contribute particularly to the promotion and establishment of implantation, reproduction, and genetic treatment. At the same time you will equip yourself with the ability to positively overcome various clinical problems.

Engineering of advanced information technologies for medicine:

This course is consisted of the following three groups: Medical Informatics group, Medical Devices for Diagnosis group, and Innovative Medical Imaging Technology group. In the course, you will learn information technologies for clinical diagnosis from their basic principles to their applications. Main target of the course is the sensing, imaging, and image processing technologies. Further, you can engage in the researches for developments of new hardware systems used ultrasound and electro-magnetic wave technologies, and of new image processing methods or systems.

Professors:

SASADA, Masataka, M.D., D.Med.Sc. (Kyoto Univ.), 1. Hematology, internal medicine, infectious disease; 2. Analysis of the mechanisms of host defense 3. Developing a new approach for the treatment of infectious diseases; 4. Analysis of the pathophysiology of inflammation mediated by neutrophils

FUKUDA, Yoshihiro, M.D., D.Med.Sc. (Kyoto Univ.), 1. Hepatology & gastroenterology; 2. Clinical immunology

FUJITA, Masatoshi, M.D., D.Med.Sc. (Kyoto Univ.), 1. Cardiology, coronary circulation, integrated physiology; 2. Clinical studies on coronary collateral circulation; 3. Congestive heart failure and coronary artery disease

OKA, Shogo, D. Pharm. Sci. (Kyoto Univ.), 1. Biochemistry, glycobiology, molecular biology, neuroscience; 2. Functional analysis of neural specific carbohydrate; 3. Glycobiological approach for the development of the nervous system

SAITO, Kuniaki, D.Med.Sci. (Fujita Health Univ.), 1. L-Tryptophan metabolisms; 2. HIV-related encephalopathy; 3. Analytical biochemistry

SUGIMOTO, Naozo, D.Eng. (Kyoto Univ.), 1. Biomedical Imaging and Image Processing; 2. Computer Aided Diagnosis Systems

SEIYAMA, Akitoshi, D.Sc. (Hokkaido Univ.), 1. Neuroscience; 2. Biophysics; 3. Biomedical Engineering

TAKAKUWA, Tetsuya, M.D., D.Med.Sc. (Osaka Univ.), 1. Experimental pathology, Oncology; 2. Experimental study on Lymphomagenesis arising in chronic inflammation

SHIINA, Tsuyoshi, D.Eng. (Univ. of Tokyo), 1. Biomedical Engineering; 2. Development of Biomedical Imaging Technologies and Diagnosis Systems; 3. Medical Ultrasonics

Associate Professors:

IKEMOTO, Masaki, M.T., D.Med.Sc. (Kyoto Univ.), 1. Clinical chemistry, biochemistry, clinical biochemistry; 2. Clinical and biochemical enzymology, immunopathology; 3. Study on human liver-type arginase and its clinical significance; 4. Study on a myeloid-related protein complex (MRP8/14) as an acute inflammatory marker

OTSUKA, Kenichi, D. Sc. (Kyoto Univ), 1. Partial differential equations; 2. Positivity of fundamental solutions for partial differential operators, asymptotic distribution of eigenvalues of elliptic partial differential operators

SASAYAMA, Satoshi, D.Med.Sc (Univ. of Tokyo), 1. Biomedical informatics, ergonomics; 2. Construction of pathogenic bacteria database system utilizing web technology; 3. Application of continuous measurements of blood pressure waveform during operation and exercise to the evaluation of cardiovascular responses

IBUKI, Kentaro, D.V.M., D.Med.Sc. (Kyoto Univ.), 1. Virology and Immunology;

Assistant Professors:

ITOH, Hiroshi, M.T., M.Med.Lab.Sc. (Tokyo Med Dent Univ.), 1. Host defense; 2. Hematology; 3. The effects of purines on neutrophil functions

UENO, Tomohiro, Ph.D. (Kyoto Univ.),

1. Low temperature physics; 2. MRI; 3. NMR

YAMAMOTO, Yasuko, M.T., C.T. (IAC), D.Med.Lab.Sc. (Osaka Univ.), 1. Molecular pathology

DEPARTMENT OF PHYSICAL THERAPY

Department of Physical Therapy is established with the aim of producing able physical therapists with international expertise, foresight and intelligence. It is also engaged in the study and development of innovative technology in the field of physical therapy, which is one of the key modalities of rehabilitation medicine. Besides professional education and training, priority is given to the development of sound medical ethics. Students are also provided with opportunities to broaden their horizons by realizing the latest frontiers of medicine at Kyoto University Hospital.

Professors:

TSUBOYAMA, Tadao, M.D., D.M.Sc. (Kyoto Univ.), 1. Orthopedics; 2. Bone metabolism; 3. Osteoporosis; 4. Musculoskeletal oncology;

KUROKI, Hiroshi, R.P.T., D.Med.Sc. (Kyoto Univ.), 1. Histology and bio-mechanics on articular cartilage; 2.Physical therapy; 3. Rehabilitation for knee osteoarthritis;

ICHIHASHI, Noriaki, R.P.T., D.Med.Sc. (Fujita Health Univ.), 1. Orthopaedic physical therapy; 2. Clinical kinesiology; 3. Physical fitness and sports medicine;

ISHIBASHI, Makoto, M.D.,Ph.D. (Kyoto Univ.), 1. Development of the central nervous system; 2. Head morphogenesis; 3. Analysis of gene regulation; 4. Cell-to-cell communication during development;

Associate Professors:

TAMAKI, Akira, R.P.T., Ph.D. (Hyogo College of Med.),

1. Pulmonary physical therapy; 2. Respiratory physiology;

KASAHARA, Katsuyuki, M.D., D.Med.Sc. (Kyoto Univ.),

1. Orthopedics; 2. Oncology; 3. Immunology;

Senior Lecturers:

OHATA, Koji, R.P.T., M.S. (Osaka Kyoiku Univ.), 1. Pediatric physical therapy; 2. Neurological physical therapy

MAEDA, Yuko, M.A. (Kyoto Univ.), 1. Medical Education 2.Public Health 3.Social Psychology

Assistant Professors:

IKEZOE, Tome, R.P.T., D.Sc. (Kobe Univ.), 1. Physical therapy for geriatrics;

TATEUCHI, Hiroshige, R.P.T., M.S. (Kobe Univ.), 1. Orthopaedic physical therapy;

Teaching Associate:

YAMADA, Minoru, R.P.T., M.S. (Kobe Univ.), 1. Orthopaedic physical therapy; 2. Physical therapy for geriatrics

DEPARTMENT OF OCCUPATIONAL THERAPY

Education outline

Occupational therapy is believed to play very important role for the rehabilitation. But in order to be recognized the importance of this profession, the effect of the occupational activities should be proved systematically, and scientifically. Our program aims at the cultivation of the occupational therapist as a profession who will be able to problem solve and further develop the profession.

Professors:

YAMANE, Hiroshi, Ph.D. (Kansai Med. Univ.), O.T.R., 1. Occupational therapy for mental disorders; 2. Group dynamics and communication;

MITANI, Akira, Ph.D. (Kyoto Univ.), 1. Physiology; 2. Neuroscience; 3. Methodology of research; health neuroscience; 4. Neural protection against ischemia; 5. Brain functional improvement induced by rehabilitation;

TOICHI, Motomi, M.D., Ph.D. (Kyoto Univ.), 1. Clinical cognitive neuroscience of psychiatric disorder (autism, Aspergerfs disorder, schizophrenia, bipolar disorder); 2. Child and adolescent psychiatry; 3. Electrophysiology (Near-infrared spectroscopy of the brain, electroencephalogram, analyses of autonomic nervous system function); 4. Forensic psychiatry;

FUTAKI, Toshiko, M.S., Ph.D. (Showa Univ.), O.T.R.,1. Occupational therapy for physical disabilities; 2. Occupational therapy for geriatrics; Rehabilitation for cognitive disorders;

Associate Professors:

KATO, Toshihiro, M.Ed., O.T.R., 1. Occupational therapy for developmental disabilities; 2. Occupational therapy for educationally handicapped children;

Assistant Professors:

KOSHIHARA, Kikue, M.S. (Occupational Therapy), O.T.R.,

1. Occupational therapy for mental disorders; 2. Activity adaptation for O.T.;

SAKAI, Hiroshi, M.S. (Occupational Therapy), O.T.R., 1. Occupational therapy for physiological disabilities; 2. Rehabilitation for higher brain dysfunctions;

SHOJI, Mikiko, B.A.(Literature), O.T.R., 1. Occupational therapy for children; 2. Supporting families of children with disability;

SHIRAI, Haruna, M.S. (Health Science), O.T.R.,

1. Well-being in dementia; 2.Occupational therapy for geriatrics;

MATSUBAYASHI, Jun, M.S. (Science), 1. Basic research for neurological rehabilitation of physical disabilities; 2. Functional brain imaging (magnetoencephalography and electroencephalography);

Teaching Associate:

ARAI, Noriko, O.T.R., 1. Occupational therapy for developmental disabilities;

CONTRIBUTED CHAIRS

DEPARTMENT OF TRANSLATIONAL CLINICAL ONCOLOGY

Dept. of Translational Clinical Oncology has launched in October, 2003 to facilitate translation of the scientific progress made during the past decade in the field of clinical research onto daily practice of clinical oncology.

Outline of Research Activities:

Our research aims are development of better chemotherapeutic regimens in order to provide better quality of care for cancer patients. To achieve this goal, we have constructed an infrastructure for clinical trials in medical oncology. Examples are the clinical trial data managing system (Cyber Oncology) and other clinical trial supporting tools. We are actively conducting and supervising many high quality clinical trials conducted at the Outpatient Oncology Unit of Kyoto University Hospital.

Outline of Teaching Activities:

Medical oncology lecture courses for physicians, pharmacists and nurses are in preparation. Graduate and undergraduate courses of medical oncology will start soon.

Outline of Clinical Activities:

We are responsible for the patients care in the Outpatient Oncology Unit of Kyoto University Hospital, where more than 30 patients, on daily average, receive infusional chemotherapy as outpatient. The Unit is managed by full-time staffs including medical oncologists, oncology pharmacists and oncology nurses. Various clinical trials are ongoing, along with the standard regimens for each cancer at the Unit.

Deputy Director and Program-Specific Associate Professor (Endowed Chair):

YANAGIHARA, Kazuhiro, M.D., D.Med.Sc. (Kyoto Univ.), 1.Medical Oncology; 2.Thoracic Surgery

Program-Specific Assistant Professors (Endowed Chair):

MATSUMOTO, Shigemi, M.D.,

1. Medical Oncology; 2.Gastroenterology

KITANO, Toshiyuki, M.D.,

1. Medical Oncology; 2.Hematology

Program-Specific Senior Lecturer (Endowed Chair);

NISHIMURA, Takafumi, M.D., Med.Sc. (Kyoto Univ.),

1. Medical Oncology; 2. Tumor Biology

DEPARTMENT OF IMMUNOLOGY AND GENOMIC MEDICINE

Immune system can react against virtually unlimited variety of foreign antigens in highly regulated manner. This phenomenon has been one of the biggest mysteries in biology. Recent advances in immunology and molecular biology are shedding light on molecular mechanisms that are operating in the system. Because they are related with various diseases, such as autoimmune, tumorigenesis, etc., the research on this field is expected to benefit clinical science as well as basic biology.

The Department of Immunology and Genomic Medicine was founded in April 2005 as a contributed chair sponsored by Ono Pharmaceutical Co., Ltd. The department aims to perform basic and translational research in Immunology and Genomic Medicine, thereby making significant contributions to bioscience and medicine. Dr. Tasuku Honjo was appointed as the professor. He is a world wide leader in the immunogenetics who received the Asahi Award, the Kihara Award of Japanese Genetic Society, the Takeda Medical Award, the Behring-Kitasato Prize, the Uehara Award and the Imperial Prize from Japan Academy. Also, he is a foreign associate of National Academy of Sciences, U.S., and honored as a person of cultural merit by Japanese government

Outline of Teaching Activities:

Teaching activities cover the following: 1. Regulation of immune response; 2. Mechanism for antibody diversification; 3. Function of cytokines; 4. Genome stability.

Outline of Research Activities:

We study molecular mechanisms controlling development and function of lymphocytes, focusing on two important questions: 1) Class switch recombination (CSR) and AID: B lymphocytes switch antibody isotypes from IgM to others adding diverse effecter functions to Ig with a given antigen specificity. We revealed this phenomenon is mediated by a region-specific recombination accompanied by deletion of Ig constant region genes from chromosomes, which is now called CSR. More recently we identified an RNA-editing enzyme AID, which we showed critical for not only CSR but also SHM, a mechanism for Ig affinity maturation. How does single AID molecule control the two totally different processes, CSR and SHM? Accumulating evidence suggests that AID binds to two separate co-factors to edit yet-to-be-identified target mRNAs required for CSR or SHM. We are now poised to discover such target mRNAs and co-factors to unveil the molecular mechanism of CSR. 2) Autoimmunity and PD-1: We showed mice deficient in PD-1, a negative regulator for immune responses, develop autoimmune diseases such as dilated cardiomyopathy and systemic lupus erythematosus. As these symptoms vary depending on genetic backgrounds of mice, we are trying to identify genes which cooperate with PD-1 and control development of autoimmune diseases.

Professor:

HONJO, Tasuku, M.D., D.Med.Sc. (Kyoto Univ.), Regulatory mechanism of lymphocyte differentiation;

Associate Professors:

NAGAOKA, Hitoshi, M.D., D.Med.Sc. (Kyoto Univ), B lymphocyte biology;

SHINKURA, Reiko, M.D., D.Med.Sc. (Kyoto Univ.), Molecular mechanism of class switch recombination;

Assistant Professors:

BEGUM, Nasim A., Ph.D. (Visvabharati Univ., India), Molecular mechanism of class switch recombination;

CHIKUMA, Shunsuke, D.V.M., Ph.D. (Medicine; Hokkaido Univ.), Genetic mechanisms of autoimmune diseases;

DEPARTMENT OF ORGAN PRESERVATION TECHNOLOGY

TEL : +81-75-751-4975

FAX : +81-75-751-4974

e-mail : orpteckuhp.kyoto-u.ac.jp

Research and Education

Transplantation of various organs including the lungs, heart, liver, kidney, islets, and small intestine has been established as a solo therapeutic option for end-stage organ dysfunction. Additionally, various therapies including bone marrow transplantation for leukemia, immunotherapy for cancer, and replantation of amputated digits are emerging.

However, the quality and quantity of organs, tissues and cells transplanted after preservation is not yet satisfactory. Therefore, elucidating the mechanisms of functional deterioration after preservation and improving the quality of organs, tissues, and cells would directly benefit patients for those advanced therapies. Reliable methods of preservation would enable the use of marginal donors and alleviate the shortage of donor organs. Good function of preserved organs, tissues, and cells would lessen complications after therapies and contribute to medical economy. Further, knowledge on organ, tissue and cell preservation would also provide better results in regenerative medicine.

Our department would like to support collaborations between many researches, and perform basic as well as pre-clinical studies.

Associate Professor:

BANDO, Toru, M.D., Ph.D. (Kyoto Univ.), Thoracic surgery

Assistant Professors:

FUJINAGA, Takuji, M.D., Ph.D. (Kyoto Univ.), Thoracic surgery

CHEN, Fengshi, M.D., Ph.D. (Kyoto Univ.), Thoracic surgery

DEPARTMENT OF RESPIRATORY CARE AND SLEEP CONTROL MEDICINE

The department of respiratory care and sleep control medicine was newly established in Kyoto University, Faculty of Medicine, in April 2008. The purpose of this department is to investigate the best respiratory care and the pathophysiology and pathogenesis of sleep disturbance and sleep-disordered breathing that have significant effects on systemic diseases.

Outline of Research Activities:

The major fields in research are follows:

1. Respiratory care for acute and chronic respiratory failure

2. Pathophysiology of sleep disturbance and sleep-disordered breathing

3. Diagnosis and treatment for sleep-disordered breathing and sleep disturbance

4. Noninvasive and invasive ventilatory support

5. Development of new strategy for respiratory care and sleep medicine

Outline of Teaching Activities:

This department is responsible for teaching respiratory failure and sleep medicine to undergraduate students and for instructing basic and clinical studies in respiratory care and sleep medicine, especially sleep disordered breathing to graduate students. For the respiratory care and sleep disordered breathing, we are also responsible for clinical training of clinical fellows and residents in the department of University Hospital.

Outline of Clinical Activities:

In cooperation with the other departments, we provide the proper respiratory care for the in-patients during awake and sleeping time including perioperative stage in the University Hospital. The department undertakes diagnosis and treatment of sleep-disordered breathing and sleep disturbance. We are also responsible for out-patient wards in the University Hospital, and taking care of patients with respiratory failure, sleep disturbance and/or sleep-disordered breathing who use noninvasive ventilator with or without the home oxygen therapy.

Professor:

CHIN, Kazuo, M.D., M.Med.Sc. (Kyoto Univ.), 1.Respiratory Insufficiency, 2.Sleep disordered breathing, 3. Respiratory medicine

Associate Professor:

TSUBOI, Tomomasa, M.D., M.Med.Sc. (Kyoto Univ.), 1.Respiratory Insufficiency, 2.Sleep disordered breathing, 3. Respiratory medicine

Senior Lecturer:

OGA, Toru, M.D., D.Med.Sc. (Kyoto Univ.), Respiratory medicine

Assistant Professor:

SUGIYAMA, Hanako, M.D. 1.Clinical Neurophysiology, 2.Brain Pathophysiology

CAREER-PATH PROMOTION UNIT FOR YOUNG LIFE SCIENTISTS

See gCAREER-PATH PROMOTION UNIT FOR YOUNG LIFE SCIENTSTSh in CENTERS pages for details.

5. RESEARCH FACILITIES

INSTITUTE OF LABORATORY ANIMALS

Director: SERIKAWA, Tadao, D.V.M., D. Agr.

Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501

Tel. +81-75-753-4489

Fax. +81-75-753-4409

The Institute of Laboratory Animals was established as one of the research institutes in the Faculty of Medicine, Kyoto University in 1972, and a new building was constructed in 2003. The building includes 6 floors covering an area of 9,400 m², and has extensive facilities for animals, laboratory experiments and operations. There are a number of caged animal rooms for mice and rats. In addition, the animal-keeping facilities have a racked cage system equipped with automatic waste-disposal, watering and feeding devices, maintaining healthy and sanitary conditions, as well as saving labor. The Institute is a core center of National BioResource Project for the Rat in Japan.

The Institute is dedicated to and actively engaged in:

1. performing animal experiments, primarily with mice, rats, hamsters, guinea pigs, rabbits, cats, dogs, and non-human primates

2. keeping and supplying various inbred and mutant strains of rats

3. carrying out education and research in laboratory animal sciences

4. offering advice on animal experiments and information on laboratory animals to medical doctors and scientists.

Professor:

SERIKAWA, Tadao, D.V. M., D. Agr. (Osaka Prefecture Univ.), Laboratory animal science

Associate Professor:

KURAMOTO, Takashi, D. Med.Sc. (Kyoto Univ.), Laboratory animal science

CONGENITAL ANOMALY RESEARCH CENTER

Director: KANEKO, Takeshi, M.D., Ph.D.

Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501

Tel. +81-75-753-4345 Fax. +81-75-753-4621

The Congenital Anomaly Research Center was established on April 1, 1975 in the Faculty of Medicine. The founder and the first Director of the Center, the late Professor Hideo Nishimura, initiated systematic collection of human embryonic and fetal specimens, especially those at the period of major organogenesis. The collection of human conceptuses was initiated in 1961 and various aspects of normal and abnormal human prenatal development have been investigated. This effort has been energetically continued in collaboration with a number of obstetricians, pediatricians, and other physicians. Most of the human prenatal specimens have been procured after termination of pregnancy for social reasons and therefore the embryo population can be regarded as a representative of the total intrauterine population in Japan. The total number of specimens collected so far exceeds 44,000. Of those specimens, approximately 1,000 cases have been histologically prepared in serial sections. The human embryo collection and associated clinical data are made available for scientific research and medical education.

The main purposes of the Center are: 1. to establish normal standards of human prenatal development; 2. to investigate the initiating processes and pathogenetic mechanisms of various congenital malformations; 3. to make genetic epidemiological studies of human congenital malformations and identify genetic and environmental factors responsible for human birth defects; 4. to make the human embryo data available for birth defects monitoring; 5. to make the Center's collection of human conceptuses available for scientific research; 6. to furnish embryonic and fetal specimens for education in medical embryology and teratology for graduate and undergraduate students; and 7. to give advice to clinicians and scientists in related fields concerning the problems of human birth defects.

In addition to the studies with human embryos and fetuses, experimental studies using animal models are also conducted to elucidate the mechanisms of abnormal development.

Associate Professor:

YAMADA, Shigehito, M.D., D.Med.Sc. (Kyoto Univ.),

1. Normal and abnormal human development; 2. Imaging of human embryos; 3. Clinical dysmorphology; 4. 3D visualization of human embryos;

CENTER FOR ANATOMICAL STUDIES

(FORMERLY STUDY CENTER FOR HUMAN REMAINS)

Director: MANABE, Toshiaki, M.D., FCAP.

Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501

Tel. +81-75-753-4496

This center was founded in 1981 as a model institution to conduct integrated research and education for gross anatomy and pathologic and forensic medicine. The building has a basement and four floors covering an area of 5,065m2. The eastern wing consists of two autopsy rooms for forensic medicine and pathology, a research laboratory and exhibition rooms for medical history, and valuable autopsy specimens. The western wing consists of a room for gross anatomy, an auditorium and two rooms for histology practice and audio-visual education. The computer-assisted educational room of the center for information and multimedia studies is also located on the 2th Floor. There is a large collection of microscopic/macroscopic specimens and pathology case records since 1900.

Professor:

MANABE, Toshiaki, M.D., FCAP., 1. Surgical pathology; 2. Pulmonary pathology; 3. Dermatopathology

Assistant Professor:

KOTANI, Hirokazu, M.D., D.Med.Sc. (Mie Univ.), Anatomic pathology;

CENTER FOR GENOMIC MEDICINE

Director: MATSUDA, Fumihiko, D.Med.Sc. (Kyoto Univ.)

Yoshida Konoe-cho, Sakyo-ku, Kyoto 606-8501

Tel. +81-75-753-4661

Fax. +81-75-753-9314

The center was established in April 2004 by converting Center for Molecular Biology and Genetics that directly was belonging to the University to join to the Graduated School of Medicine. A part of Department of Genome Epidemiology in the Graduate curriculum of Public Health was also converted to join to this center. Major research aim of the center is to identify the genes responsible for the onset and progression of human multigenetic disorders and to analyze their function. The center consists of two units, Unit of Human Disease Genomics and Unit of Genome Informatics. The third unit, Unit of Statistical Genetics will soon be created. In January 2007, a research unit for trans-ethnic genetic studies of multigenetic disorders (Unit 852) was created with financial support of Institute National de la Santé et de la Rechérche Médicale (INSERM) in France to further reinforce international collaboration in the field of genomics.

The Center mainly occupies approximately 500 in the departments in the graduate curriculum in the Medical School.

Unit of Human Disease Genomics

Study of human diseases based on genetic information is one of the most important subjects in the Post Genome Project. In particular, to overcome human multigenetic disorders, it is essential to perform trans-ethnic genetic analyses of human genome variations. In our unit, we perform genome wide association studies (GWAS) of a variety of diseases with SNP arrays using DNA samples (at the order of 1,000) of disease patients and control subjects from different ethnic origins. The projects include rheumatoid arthritis, chronic HCV disease, radiation-induced childhood thyroid cancer, lung cancer and adult T-cell leukemia. We try to establish a new generation genome variation-based genomic strategy which will be directly linked to clinical research and therapeutics.

Professor:

MATSUDA, Fumihiko, D.Med.Sc. (Kyoto Univ.), 1. Molecular biology; 2. Human genetics;

Associate Professor:

KADOTANI, Hiroshi, M.D., D.Med.Sc. (Kyoto Univ.), 1. Sleep Research; 2. Epidemiology;

Associate Professor of Industry-Government-Academia Collaboration:

MURAKAMI, Yoshiki, M.D., Ph.D. (Kyoto Prefectural University of Medicine), 1.Virology; 2.Hepatology;

Research Associate:

TAKAHASHI, Meiko, Ph.D. (University of London), Cancer genetics;

Research Scientist:

TAKIGAWA-IMAMURA, Hisako, D. Sc. (The Graduate University of Advanced Studies), 1. Mathematical biology; 2. Molecular biology;

Unit of Genome Informatics

Major goal of research in this unit is

(1) to establish bioinformatics system which can handle large-scale disease genomics studies such as GWAS, prospective cohort studies and whole genome sequencing approaches. This includes the construction of a comprehensive SNP database of different multigenetic diseases which integrates genetic and clinical information.

(2) to understand molecular mechanisms underlying gene regulation and genome evolution by comparative genomic approaches. The projects involve (i) identification of regulatory elements, such as transcription factor binding sites and splicing regulators, and (ii) molecular evolutionary analyses of gene duplications and genome rearrangements.

Professor:

SEKINE, Akihiro, D.Med.Sc. (Kyoto Univ.), Human Genetics;

Associate Professor:

SUYAMA, Mikita, D.Agr.Sc. (Kyoto Univ.), Comparative Genomics;

Research Scientist:

MIZUSAWA, Seiho, M.Sc. (Tsukuba Univ.), Human Genetics;

CENTER FOR MEDICAL EDUCATION

Director: HIRAIDE, Atsushi, M.D., D.Med.Sc. (Osaka Univ.)

Yoshida Konoe-cho, Sakyo-ku, Kyoto 606-8501

Tel: +81-75-753-9338

Fax: +81-75-753-9339

http://plaza.umin.ac.jp/~cme/index.html

In these days, topics concerning about medical education became one of important issues for our community. Traditional style of medical education has been carried out mainly by the effort of individual department of medical school. It has been, however, impossible nowadays that we provide a qualified medical education without coordination of the effort of individual section. Center for Medical Education has been newly established in 2004 to act a central role for promotion of a qualified medical education.

Outline of Teaching and Research Activities:

Center for Medical Education is not one of departments in medical school. It has been established in order to promote medical education as a faculty. Therefore it is not for a specific research or an education carried out in individual department.

Now the center is revising the framework of curriculum of basic medicine for biomedical science and public health.

We are also changing our clinical training course to a clinical clerkship-based new pathway instead of a traditional bed-side learning curriculum. Our activity is also concerned with the post-graduate resident course.

Not only in making a better system for medical education, the center is also engaged in a development of programs for learning, such as a new program for Medical English in basic field, and a practical resuscitation program for sudden cardiac arrest patients in clinical field.

Professor:

HIRAIDE, Atsushi, M.D., D.Med.Sc. (Osaka Univ.), 1.Medical education; 2.Emergency medicine; 3.Resuscitation;

Senior Lecturer:

MORIMOTO, Takeshi, M.D., D.Med.Sc. (Kyoto Univ.), M.P.H.(Harvard Univ.), 1. Medical Education; 2. Clinical Epidemiology; 3. Patient Safety; 4. General Internal Medicine;

Assistant Professors:

SAKUMA, Mio, M.D., D.Med.Sc. (Jikei Univ. school of Medicine), M.P.H.(Harvard Univ.), 1. Medical Education;

2. Clinical Epidemiology; 3. Pediatrics;

Teaching Associate:

SEKI, Susumu, 1. Medical Education; 2. Human Interface;

HUMAN BRAIN RESEARCH CENTER

In April 2000, the Human Brain Research Center was newly founded in affiliation with the Graduate School of Medicine in order to further advance the studies of human brain functions using various modern technologies such as electrophysiology, magnetoencephalography, positron emission tomography, single photon emission computed tomography, functional magnetic resonance imaging, and transcranial magnetic stimulation. The Center is formed of three Departments; Brain Pathophysiology, Functional Brain Imaging, and Psychophysiology. Professor Hidenao Fukuyama, M.D. is serving as the Director of the Research Center. The Department of Brain Pathophysiology which belonged to the Graduate School of Medicine moved to this Center, becoming its principal constituent. The Department of Functional Brain Imaging is mainly developing the methods of magnetic resonance imaging of the human brain and detecting functional brain activation by metabolic or blood flow change. The Department of Psychophysiology invites a foreign scientist each year. In order to explore more widened view of human brain function, this center is actively collaborating with faculties of letters, pharmaceutical sciences, and engineering.

Department of Brain Pathophysiology

This Department was founded in April 1990 as one of the three core sub-departments forming a new post-graduate course in the Faculty of Medicine called the Division of Integrative Brain Medical Science. Since 1995 it belonged to the Section of Clinical Neuroscience as a result of a change from the Faculty of Medicine to the Post-Graduate Course of Medical Science. The primary aim of this Department is to clarify the mechanisms underlying brain activities such as cognitive, motor and memory functions in normal humans and their disturbances in patients with various diseases affecting the higher brain functions. In order to accomplish this aim, this department mainly utilizes electrophysiological measures which preferentially resolve temporal profiles of brain activities. As described above, the Department has belonged to the newly founded Human Brain Research Center since April 2000.

Associate Professor:

MIMA, Tatsuya, M.D., D.Med.Sc. (Kyoto Univ.), Electrophysiology of the central nervous system and motor control;

Assistant Professor:

SAWAMOTO, Nobukatsu, M.D., D.Med.Sc. (Kyoto Univ.), Basal ganglia function and its dysfunction;

Department of Functional Brain Imaging

The Department of Functional Brain Imaging was newly developed at the beginning of this center. Professor Fukuyama, M.D. was affiliated as the chairman of this department since January 1st, 2001. This department is dedicated to the examination and research works on the neurological disorders and neuronal functions using brain imaging techniques, such as positron emission tomography, single photon emission CT and MRI. These measures are specifically adequate to unravel brain functions from the viewpoint of spatial extent and its connectivity. In collaboration with the Department of Brain Pathophysiology, we try to disclose functional aspect of neurological disorders as well as the neuronal mechanisms in the healthy human subjects.

Professor:

FUKUYAMA, Hidenao, M.D., D.Med.Sc. (Kyoto Univ.), PET studies on neurological disorders and brain functions;

Associate Professor:

YAMAUCHI, Hiroshi, M.D., D.Med.Sc. (Kyoto Univ.)

PET examinations on Neurological disorders;

Assistant Professor:

URAYAMA, Shin-ichi, M.Sc. (Kyoto Univ.), Development of analytical procedures for neuroimaging studies;

KUMBL (Kyoto University Medical Science and Business Liaison Organization)

-THE BRIDGE BETWEEN LABORATORY AND

INDUSTRY IN THE FIELD OF MEDICINE-

As a run-up to the incorporation of national university, in April 2002, Graduate School of Medicine set up a Business Liaison Office (which formed a part of KUMBL) as one of its measure to promote the exploitation its research outcome; one of the three important missions to be fulfilled along with its mission of education and research.

Since the incorporation in April 2004, it continued to grow to provide wider support for academia-industry relations not only for Graduate School of Medicine but also for other schools and institutes in the field of medical science.

In April 2005, it launched its sub-wing, Incubation Plaza to support the establishment of spin-out companies. Till date, it has held a number of national and international symposiums and seminars in cooperation with the Management of Technology in Medical Science Course and provided much support to faculties and laboratories in promoting their research and developing the relationship with industry.

LIAISON AND COORDINATION

KUMBL provide supports for Industry-Academia relations (1) by excavating and collating the seed technology (both disclosed and undisclosed), which may potentially become the subject of collaboration with industry, (2) by disclosing the latest information at Kyoto University on research activities, drug-development/ clinical investigation, life and medical ethics, and on other information as may be requested by the public, and (3) by providing advice and support to each industry-academia collaborations (e.g. development of a new drug or medical instrument).

PATENT PROSECUTION

In cooperation with the Office of Society-Academia Collaboration for Innovation (SACI), administration office, and Innovative Collaboration Center (ICC), KUMBL provides administrative supports for filing of patent by coordinating between researchers and administration.

LICENSING

In cooperation with Shirankai Business Liaison Office, KUMBL discloses newly filed patents selected by the Invention Evaluation Committee (Medical and Bioscience Division) of Kyoto University to Shiran Society (a membership society consisting mainly of pharmaceutical companies).

MATERIAL TRANSFER

KUMBL supports the execution of MTA (Material Transfer Agreement) for provision and receipt of research materials (e.g. cells, DNA etc.) to and from other universities or companies in and outside Japan.

EDUCATION

Through hosting seminars and symposiums, KUMBL provides latest information from in and outside Japan relating to research and intellectual property. KUMBL also supports Management of Technology and Intellectual Property, which fosters human resources who are capable of working for industry-academia relations.

START-UP SUPPORT (INCUBATION PLAZA)

To promote the return of research outcome to society, Mitsubishi UFJ Capital Co., Ltd. and Sumitomo Corporation together take part to form Incubation Program Committee set up within KUMBL. From April 2005, operating under the name gIncubation Plazah, it selects projects to invest and form university spin-out companies. The spin-out will collaborate with university to further develop the research base for business application.

Director-General:

MITSUYAMA, Masao, M.D., Ph.D. Professor (Kyoto Univ.), Dean, Kyoto University Graduate School of Medicine

Deputy Director:

TERANISHI, Yutaka, D. Eng. (Kyoto Univ.), Professor, Management of Technology and Intellectual Property,, School of Public Health, Graduate School of Medicine; Industrial Relations Manager, Business Liaison Office of Faculty of Medicine

Email:

URL: http://www.med.kyoto-u.ac.jp/J/KUMBL

*The name gmedical science fieldh indicates Faculty of Medicine, Graduate School of Medicine, Faculty of Pharmacy, Graduate School of Pharmacy, Graduate School of Biostudies, Institute for Virus Research, Institute for Frontier Medical Science, Kyoto University Hospital, and related field such as Primate Research Institute and Radium Biology-Center.